Interfaces, circuits and humidifiers

Copyright © 2020 Ferreira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Long-term non-invasive ventilation (LTNIV) has been increasingly used in children to manage chronic respiratory failure and airway obstruction. Interfaces are of paramount importance for non-invasive ventilation (NIV) effectiveness and patient compliance. However, historically, the choice of pediatric mask has been limited by the scarce availability of commercial interfaces. In recent years, an increasing number of different masks have been commercialized for children, allowing to increase the number of patients who could benefit from LTNIV. Factors such as the age of the child, disease, craniofacial conformation, type of ventilator and mode of ventilation, and children's and family's preferences should be taken into account when selecting the appropriate mask. Adverse events such as skin lesions, facial growth impairment, and leaks must be prevented and promptly corrected. Humidification is a controversial issue on NIV, but it may be useful in certain circumstances. Regular cleaning and disinfection of interfaces and equipment must be addressed. During follow-up, educational programs, close supervision, and continuous support to children and families are crucial to the success of LTNIV therapy.info:eu-repo/semantics/publishedVersio

Youth Involvement in Street Gangs: Obstacles of Leaving Street Gangs

Even though there seems to be a good number of youth programs that focus on youth street gang prevention, there is a shortage of programs that offer opportunities so youth can leave street gangs and promote a street gang-free lifestyle (Young & Gonzalez, 2013). The workshop, Obstacles of Leaving Street Gangs, intended to engage local community residents and organizations who do youth programming in a meaningful discussion about street gangs and the obstacles to leave and also share personal stories of people who have successfully left street gangs. This workshop also meant to share resources that help with these obstacles. It was found that even though every participant who responded to the post-workshop survey has some level of higher education (Bachelors, Masters, trade school training, and Associates), and some of them (42.9%) even work in organizations that deal with street gangs, they still have a lot to learn about street gangs and how they work. This workshop also highlighted the importance of storytelling for social justice workshops like this one because they seem to help humanize street gang members and help the participants empathize with them

New records of Orchids from Morocco

The exploration of the Rif Valley (Morocco) during 2010 revealed the presence of some new taxa and records from Morocco. The new taxa are: Orchis langei subsp. magrebensis and Ophrys neglecta var. riphaea. Ophrys neglecta var. neglecta and Ophrys numida have been detected for the first time in Morocco

Taquicardia ventricular: apresentação de linfoma com infiltração cardíaca

© 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L.U. All rights reserved.A 53-year-old man, with a 15-year history of mycosis fungoides (MF), presented with fever, dizziness, and presyncope. On examination, he was tachycardic (180 bpm) and hypotensive (100/70 mmHg). The ECG showed diffuse ST-segment depression, and cardiac troponin I was elevated (3.47 ng/ml). He was admitted with a suspected acute coronary syndrome. On the third day of hospitalization there were several episodes of sustained monomorphic ventricular tachycardia (MVT).info:eu-repo/semantics/publishedVersio

Omalizumab induced Takotsubo syndrome : case report

© The Author(s) 2019.The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected]: Omalizumab is a humanized monoclonal anti-immunoglobulin E antibody, approved for the treatment of spontaneous chronic urticaria, with high efficacy and an excellent safety profile. Although its adverse effects are rare, allergic reactions and cardiovascular events were previously described. Case summary: The authors describe the case of a 75-year-old woman, followed at the outpatient dermatology clinic due to spontaneous chronic urticaria, treated with omalizumab 300 mg every 4 weeks. After the 11th administration of omalizumab, the patient developed an episode of thoracalgia associated with electro- and echocardiographic abnormalities. Coronary angiogram excluded coronary artery disease, and left ventriculography demonstrated mid-apical akinesia and basal hyperkinesia, consistent with the Takotsubo syndrome (TS). Discussion: Takotsubo syndrome was already reported in association with other monoclonal antibodies. However, to our knowledge, this is the first case of TS following the administration of omalizumab.info:eu-repo/semantics/publishedVersio

Cooperação financeira internacional : atuação dos bancos de desenvolvimento na América do Sul

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Administração, Contabilidade e Economia, Departamento de Economia, 2019.Esta monografia apresenta uma revisão bibliográfica acerca da atuação dos bancos públicos de desenvolvimento na América do Sul, mais especificamente o BNDES e a CAF, com o intuito de reunir algumas informações sobre a relação que esses bancos têm com os países da região. Além disso, neste trabalho, há um levantamento bibliográfico da literatura econômica que analisa a importância que os bancos públicos exercem por financiar a infraestrutura econômica de diversos países, sobretudo daqueles que não encontram tanta facilidade em ter acesso a mecanismos de crédito de longo prazo com taxas de juros mais acessíveis, justificando, dessa forma, a importância que estas instituições têm em países em desenvolvimento, como os sul-americanos.This paper presents a bibliographic review about two public development banks in South America, more specifically the BNDES and CAF, with the intention of gathering some information about the relationship that these banks have with the countries of the region. Moreover, in this work, there is a literature review of the economic literature that analyzes the importance that public banks exercise for financing the economic infrastructure of several countries, especially those that do not find it so easy to have access to long-term credit mechanisms with, thus justifying the importance that these institutions have in developing countries, such as South Americans

Adaptación de la célula β en dislipemia e insulinoresistencia inducida por dieta rica en sacarosa. Rol de la glucoquinasa

Animales alimentados con dieta rica en sacarosa (DRS) presentan dislipemia y resistencia insulínica (RI), que evoluciona con la cronicidad de la dieta desde normoglucemia e hiperinsulinemia a moderada hiperglucemia y normoinsulinemia, deteriorándose progresivamente el patrón de secreción de insulina. El objetivo del presente trabajo fue evaluar si cambios en la actividad de las enzimas fosforilantes de la glucosa (glucoquinasa y hexoquinasa) en la célula beta estarían involucrados en la alterada secreción de insulina observada en estos animales. Ratas Wistar recibieron DRS o dieta control (DC) durante 3 o 30 semanas. Cuando la DRS se administró por un corto período de tiempo (3 semanas) no se observaron cambios en la actividad de las enzimas. Luego de un período prolongado de ingesta de DRS la actividad glucoquinasa disminuyó sin cambios en la actividad hexoquinasa. La menor actividad glucoquinasa podría ser uno de los factores involucrados en la deteriorada secreción de insulina observada en animales alimentados crónicamente con DRS.β cell adaptation in dyslipemia and insulin resistance induced by sucrose rich diet. Role of Glucokinase. Animals fed a sucrose rich diet (SRD) show dyslipemia and insulin resistance (IR) that evolve from normoglycemia and hyperinsulinemia to moderate hyperglycemia and normoinsulinemia with the length of time the diet is consumed. This is accompanied by a progressive deterioration in insulin secretion pattern. The aim of the present work was to evaluate if changes in the activity of β cell glucose phosphorylating enzymes (glucokinase and hexokinase) would be involved in the altered insulin secretion observed in this animals. Wistar rats received SRD or control diet (CD) for 3 or 30 weeks. When the SRD was administered for a short period of time (3 weeks) no changes were observed in the activity of both enzymes. After a prolonged period of SRD intake glucokinase activity decreased without changes in hexokinase activity. The decreased glucokinase activity could be some of the factors involved in the impaired insulin secretion observed in animals fed chronically a sucrose rich diet.Fil: Ferreira Cordoneda, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Bolzon, Yolanda Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentin

Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism

This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were increased. This work shows that an increase in the key factors levels associated with muscle oxidative capacity and a reduction in the lipogenic pathway would be some mechanisms involved in the beneficial effects of chia seed on skeletal muscle lipotoxicity in insulin resistant SRD-fed rats.Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; ArgentinaFil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentin

Commencement Program, December (2016)

https://red.mnstate.edu/commencement/1194/thumbnail.jp

Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model

Interactions of several microbial pathogens with the plasminogen system increase their invasive potential. In this study, we show that Streptococcus agalactiae binds human plasminogen which can be subsequently activated to plasmin, thus generating a proteolytic bacterium. S. agalactiae binds plasminogen via the direct pathway, using plasminogen receptors, and via the indirect pathway through fibrinogen receptors. The glyceraldehyde-3-phosphate dehydrogenase is one If the S. agalactiae proteins that bind plasminogen. Presence of exogenous activators such as uPA and tPA are required to activate bound plasminogen. Results from competitive inhibition assays indicate that binding is partially mediated through the lysine binding sites of plasminogen. Following plasminogen binding and activation, S. agalactiae is able to degrade in vitro fibronectin, one of the host extracellular matrix proteins. Moreover, incubation of S. agalactiae with either plasminogen alone, or plasminogen plus fibrinogen, in the presence of tPA enhanced its virulence in C57BL/6 mice, suggesting that acquisition of plasmin-like activity by the bacteria increase their invasiveness